Microwave assisted synthesis of novel tetrazole/sulfonamide derivatives based on octahydroacridine, xanthene and chromene skeletons as inhibitors of the carbonic anhydrases isoforms I, II, IV and VII

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• 作者：İbrahim Esirden^a ; Muhammet Tanç ; ^b ; Claudiu T. Supuran^b ; ^{claudiu.supuran@unifi.it} ; Muharrem Kaya^c ; ^{muharrem.kaya@dpu.edu.tr}
• 关键词：Tetrazole ; Sulfonamide ; Octahydroacridine ; Chromene ; Carbonic anhydrase ; Enzyme inhibition
• 刊名：Bioorganic & Medicinal Chemistry Letters
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：27
• 期：1
• 页码：86-89
• 全文大小：386 K
• 卷排序：27

文摘

Synthesis tetrazoles/sulfonamides conjugate octahydroacridine, xanthene, chromene. Characterization of compounds with FT-IR, 1H NMR, 13C NMR (APT), HRMS. The synthesized new compounds have potential interesting biological properties. The inhibition profile investigated against hCA I, II, IV and VII isoforms. Noticeable inhibition profile of octahydroacridine conjugate sulfonamides.