Expression of a dynamin 2 mutant associated with Charcot-Marie-Tooth disease leads to aberrant actin dynamics and lamellipodia formation
详细信息 查看全文
- 作者：Hiroshi Yamadaa ; b ; Kinue Kobayashia ; 1 ; Yubai Zhanga ; Tetsuya Takedaa ; b ; Kohji Takeia ; b ; kohji@md.okayama-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Charcot-Marie-Tooth disease ; Dynamin ; Actin ; Stress fiber ; Endocytosis
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：15 August 2016
- 年：2016
- 卷：628
- 期：Complete
- 页码：179-185
- 全文大小：1997 K
文摘
- abel">•
The expression of dynamin mutants 555Δ3 and K562E decreased lamellipodia formation.
- abel">•
The K562E mutation caused the disappearance of radially aligned actin bundles.
- abel">•
The K562E mutation caused the appearance of F-actin clusters.
- abel">•
Short F-actin assembled into immobile F-actin clusters in K562E-expressing cells.