Synthesis of highly substituted isocoumarins by rhodium-catalyzed annulation of readily available benzoic acids

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• 作者：Yuto Unoh ; Koji Hirano ; Tetsuya Satoh ; ^{satoh@chem.eng.osaka-u.ac.jp} ; Masahiro Miura ; ^{miura@chem.eng.osaka-u.ac.jp}
• 关键词：Annulation ; C&ndash ; C coupling ; C&ndash ; H activation ; Carboxylic acids ; Rhodium
• 刊名：Tetrahedron
• 出版年：2013
• 出版时间：3 June, 2013
• 年：2013
• 卷：69
• 期：22
• 页码：4454-4458
• 全文大小：618 K

文摘

Readily available benzoic acids possessing a number of oxygen-containing group(s) efficiently undergo oxidative coupling with alkynes through regioselective C-H bond cleavage under rhodium catalysis to form highly substituted isocoumarin derivatives. Such isocoumarins are of considerable interest due to their unique biological properties.