刊名:Biochemical and Biophysical Research Communications
出版年:2017
出版时间:29 January 2017
年:2017
卷:483
期:1
页码:101-106
全文大小:1002 K
卷排序:483
文摘
A novel peptidic TrkB agonist was identified by direct agonistic phage screening. The peptide had no sequence similarity to BDNF. The peptide bound to TrkB-Fc with high affinity (binding EC50 = 0.45 nM). The peptide dimer induced the homodimerization and activation of TrkB.