Osteoblasts of calvaria induce higher numbers of osteoclasts than osteoblasts from long bone
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- 作者：Qilong Wana ; c ; Ton Schoenmakerb ; Ineke D.C. Jansenb ; Zhuan Bianc ; Teun J. de Vriesb ; Vincent Evertsa ; v.everts@acta.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：Osteoclast heterogeneity ; Osteoblast ; Co-culture ; Calvaria ; Long bone
- 刊名：Bone
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：86
- 期：Complete
- 页码：10-21
- 全文大小：2307 K
文摘
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We evaluated possible differences in the capacity of calvaria and long bone osteoblasts to induce osteoclast formation.
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Calvaria osteoblasts induce far more osteoclasts than long bone osteoblasts.
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The ratio of RANKL/OPG was higher for calvaria osteoblasts than for long bone osteoblasts.
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VitD3 pre-stimulation increased the capacity of long bone osteoblasts to induce osteoclastogenesis.