文摘
H2S, a newly discovered gaso-neurotransmitter, signals inside the cells mostly via sulfhydration of proteins. Modulation of autophagy by H2S signaling pathway is implicated in ischemia, myocardial fibrosis, metabolic disorders, and traumatic brain injury. H2S affects cellular metabolism, which affects tumor growth and angiogenesis. The maintenance, proliferation, and differentiation of stem cells are regulated by H2S. The influence of H2S signaling in cell cycle and cell death pathways is associated with cancer and neurodegenerative diseases.