Common pathways regulate Type III TGFβ receptor-dependent cell invasion in epicardial and endocardial cells
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- 作者：Cynthia R. Clarka ; 1 ; cynthia.r.allison@vanderbilt.edu" class="auth_mail" title="E-mail the corresponding author ; Jamille Y. Robinsona ; 1 ; jamille.robinson@vanderbilt.edu" class="auth_mail" title="E-mail the corresponding author ; Nora S. Sancheza ; NSSanchez@mdanderson.org" class="auth_mail" title="E-mail the corresponding author ; Todd A. Townsenda ; ttownsend@genetics.utah.edu" class="auth_mail" title="E-mail the corresponding author ; Julian A. Arrietaa ; julian.a.arrieta@Vanderbilt.edu" class="auth_mail" title="E-mail the corresponding author ; W. David Merrymanc ; david.merryman@vanderbilt.edu" class="auth_mail" title="E-mail the corresponding author ; David Z. Trykalla ; david.trykall@vanderbilt.edu" class="auth_mail" title="E-mail the corresponding author ; Harold E. Oliveyd ; holivey@iun.edu" class="auth_mail" title="E-mail the corresponding author ; Charles C. Hongb ; e ; charles.c.hong@vanderbilt.edu" class="auth_mail" title="E-mail the corresponding author ; Joey V. Barnetta ; b ; joey.barnett@vanderbilt.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：βArr2 ; beta-arrestin2 ; ALK ; activin receptor-like kinases ; AV ; atrioventricular ; BMP ; bone morphogenetic protein ; ca ; constitutively active ; EMT ; Epithelial&ndash ; Mesenchymal Transformation ; FGF ; fibroblast growth factor ; GFP ; green fluorescent protein ; GIPC ; GAIP-interacting protein ; C terminus ; IκB ; inhibitor of kappa B protein ; IKK ; I kappa B kinase ; NF-κB ; nuclear factor-kappa B ; qRT-P SMαA ; smooth muscle alpha actin ; TGFβ ; Transforming Growth Factor Beta ; TGFβR1 ; Type I TGFβ receptor ; TGFβR
- 刊名：Cellular Signalling
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：28
- 期：6
- 页码：688-698
- 全文大小：1697 K
文摘
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A TGFβR3 mutant (TGFβR3-T841A) initiates ligand-independent invasion.
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Epicardial and endocardial cell invasion requires activation of the NF-κB pathway.
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ALKs mediate both ligand-dependent and ligand-independent invasion.
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NFκB and ALK pathways may interact but both are independently required for invasion.