Anti-vascular inflammatory effects of pentacyclic triterpenoids from Astilbe rivularis in vitro and in vivo

详细信息    查看全文

• 作者：Hyejin Kang^a ; ¹ ; Sae-Kwang Ku^b ; ¹ ; Jongdoo Kim^c ; ¹ ; Jiwoo Chung^a ; Sang Chan Kim^d ; Wei Zhou^e ; MinKyun Na^f ; ^{mkna@cnu.ac.kr} ; Jong-Sup Bae^a ; ^{baejs@knu.ac.kr}
• 关键词：Astilbe rivularis ; C-27 Carboxylated pentacyclic triterpenoids ; TGFBIp ; Inflammation ; Sepsis
• 刊名：Chemico-Biological Interactions
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：261
• 期：Complete
• 页码：127-138
• 全文大小：2456 K
• 卷排序：261

文摘

Transforming growth factor β induced protein (TGFBIp) is an important extracellular mediator of sepsis. C-27 Carboxylated pentacyclic triterpenoids inhibited LPS-induced secretion of TGFBIp. C-27 Carboxylated pentacyclic triterpenoids inhibited TGFBIp-mediated hyperpermeability. C-27 Carboxylated pentacyclic triterpenoids inhibited TGFBIp-mediated septic response. C-27 Carboxylated pentacyclic triterpenoids reduced TGFBIp-induced septic mortality.