Dendritic cells tip the balance towards induction of regulatory T cells upon priming in experimental autoimmune encephalomyelitis

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• 作者：Magdalena Paterka^a ; ¹ ; Jan Oliver Voss^b ; ¹ ; ³ ; Johannes Werr^b ; ¹ ; ⁴ ; Eva Reuter^a ; Sophia Franck^a ; Tina Leuenberger^b ; Josephine Herz^b ; ⁵ ; Helena Radbruch^b ; ⁶ ; Tobias Bopp^c ; Volker Siffrin^a ; ² ; Frauke Zipp^a ; ² ; ^{frauke.zipp@unimedizin-mainz.de}
• 关键词：EAE ; Dendritic cells ; Immune regulation ; Th17 ; Treg cells ; Multiple sclerosis
• 刊名：Journal of Autoimmunity
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：76
• 期：Complete
• 页码：108-114
• 全文大小：1933 K
• 卷排序：76

文摘

Dendritic cells are potential therapeutic targets in autoimmune neuroinflammation. Studied with transgenic mice and experimental autoimmune encephalomyelitis (EAE). Conditional ablation of DCs during disease initiation leads to exacerbated EAE course. No increase in regulatory T cells (Treg) in secondary lymphoid organs and CNS. Evidence for a protective role of DCs in the initiating phase of EAE.