Comparison of sedation scores and propofol induction doses in dogs after intramuscular administration of dexmedetomidine alone or in combination with methadone, midazolam, or methadone plus midazolam
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Methadone improved sedation produced by a low-dose of dexmedetomidine in dogs.

Midazolam did not improve dexmedetomidine sedation.

Midazolam did not potentiate a combination of dexmedetomidine and methadone.

Addition of either methadone or midazolam reduced propofol requirements in dogs.

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