Serum YKL-40 in young patients with β-thalassemia major: Relation to hepatitis C virus infection, liver stiffness by transient elastography and cardiovascular complications

详细信息    查看全文

• 作者：Mohamed Abo El-Asrar^a ; Nancy Samir Elbarbary^a ; ; Eman Abdel Rahman Ismail^b ; Ahmed Mohamed Elshenity^a
• 关键词：β-thalassemia ; YKL-40 ; Liver fibrosis ; Transient elastography ; Hepatitis C ; Cardiac disease ; Iron overload
• 刊名：Blood Cells, Molecules and Diseases
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：56
• 期：1
• 页码：1-8
• 全文大小：494 K

文摘

YKL-40 is an inflammatory glycoprotein involved in endothelial dysfunction and elevated in sera of patients with liver diseases.

Aim

To determine serum YKL-40 among 50 children and adolescents with β-thalassemia major (β-TM) compared to 35 healthy controls and assess its relation to liver stiffness by transient elastography (TE), markers of hemolysis, iron overload and various hemolysis-associated complications.

Methods

β-TM patients asymptomatic for heart disease were studied stressing on chelation therapy, serum ferritin, liver iron concentration (LIC), cardiac T2* and YKL-40. Echocardiography and TE were performed.

Results

Liver cirrhosis (METAVIR F4; TE values > 12.5 kPa) was encountered in 32%. HCV-positive patients had significantly higher WBC count, alanine transaminase (ALT) and serum ferritin than HCV-negative patients. YKL-40 levels were significantly higher in β-TM patients compared with control (p < 0.001). YKL-40 was significantly higher among patients with heart disease (p = 0.014) or hepatitis C virus (p = 0.004) than those without. YKL-40 was correlated with liver stiffness and the degree of hepatic fibrosis being highest among patients with F4 stage (p < 0.001). The YKL-40 cutoff to identify β-TM patients with liver cirrhosis or heart disease was determined. Patients treated with combined chelation therapy had significantly lower levels of YKL-40 than the monotherapy group (p < 0.001). YKL-40 was positively correlated with transfusion index, ALT, lactate dehydrogenase, serum ferritin and LIC but negatively correlated with cardiac T2*.

Conclusion

YKL-40 is a promising marker of cardiovascular disease and liver siderosis in β-TM patients. The combination of YKL-40 and TE provides a reliable method to assess hepatic fibrosis in young β-TM patients.