Total Antioxidant Capacity in beta-thalassemia: A systematic review and meta-analysis of case-control studies

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• 作者：Husseen Manafikhi^a ; Gregor Drummen^b ; Maura Palmery^a ; Ilaria Peluso^c ; ^{i.peluso@tiscali.it} ; ^{ilaria.peluso@crea.gov.it}
• 关键词：Beta-thalassemia ; Bilirubin ; Meta-analysis ; Total Antioxidant Capacity ; Uric acid
• 刊名：Critical Reviews in Oncology/Hematology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：110
• 期：Complete
• 页码：35-42
• 全文大小：998 K
• 卷排序：110

文摘

Total Antioxidant Capacity (TAC) is decreased in thalassemics versus healthy subjects. Similar decreased TAC levels were found in beta-thalassemia major and trait. No relationship between TAC and disease severity could be established. The possible interference of uric acid and bilirubin must be taken into account. Uric acid-independent TAC might be the better approach to evaluate antioxidant status.