Gamma-hydroxybutyric acid

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• 作者：Ruben Thanacoody
• 关键词：CNS depression ; coma ; drug abuse ; drug withdrawal ; GABA receptor ; gamma-hydroxybutyric acid
• 刊名：Medicine
• 出版年：2007
• 出版时间：November 2007
• 年：2007
• 卷：35
• 期：11
• 页码：619
• 全文大小：47 K

文摘

Gamma-hydroxybutyric acid (GHB; liquid ecstasy, sodium oxybate) is a drug of abuse which is increasingly used recreationally and has been implicated in cases of ‘drug rape’. GHB-intoxicated patients may appear sedated or may show paradoxical agitation. After ingestion of a toxic amount of GHB, rapid onset of respiratory depression and deep coma may occur, resolving spontaneously within 24 hours with supportive care. In regular users, a withdrawal syndrome similar to alcohol withdrawal is also recognized.