A synthetic 2,3-diarylindole induces cell death via apoptosis and autophagy in A549 lung cancer cells

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• 作者：Thanya Rukkijakan^a ; Lukana Ngiwsara^b ; ^{lukana@cri.or.th" class="auth_mail" title="E-mail the corresponding author} ; Kriengsak Lirdprapamongkol^b ; Jisnuson Svasti^b ; Nared Phetrak^a ; Pitak Chuawong^a ; ^{Pitak.C@ku.ac.th" class="auth_mail" title="E-mail the corresponding author}
• 关键词：2 ; 3-Diarylindole ; Apoptosis ; Autophagy ; Lung cancer
• 刊名：Bioorganic & Medicinal Chemistry Letters
• 出版年：2016
• 出版时间：1 May 2016
• 年：2016
• 卷：26
• 期：9
• 页码：2119-2123
• 全文大小：2101 K

文摘

A series of 2,3-diarylindoles were synthesized via the Larock heteroannulation, and evaluated for their anticancer activity against A549 lung cancer cells. The most potent compound, PCNT13 with IC₅₀ = 5.17 μM, caused the induction of two modes of programmed cell death, apoptosis and autophagy.