Systems biology of neutrophil differentiation and immune response
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- 作者：Kim Theilgaard-Mö ; nch ; Bo T Porse and Niels Borregaard
- 刊名：Current Opinion in Immunology
- 出版年：2006
- 出版时间：February 2006
- 年：2006
- 卷：18
- 期：1
- 页码：54-60
- 全文大小：454 K
文摘
Systems biology has emerged as a new scientific field, which aims at investigating biological processes at the genomic and proteomic levels. Recent studies have unravelled aspects of neutrophil differentiation and immune responses at the systems level using high-throughput technologies. These studies have identified a plethora of novel effector proteins stored in the granules of neutrophils. In addition, these studies provide evidence that neutrophil differentiation and immune response are governed by a highly coordinated transcriptional programme that regulates cellular fate and function in a context-dependent manner.