Endothelin-1-induced remodelling of murine adult ventricular myocytes
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- 作者：Cedric Vieroa ; 1 ; Silke Wegenera ; 2 ; Anke Scholza ; Sandra Ruppenthala ; Qinghai Tiana ; Wiebke Tabelliona ; 3 ; Michael Kreinesta ; 4 ; Matthias W. Laschkeb ; Lars Kaestnera ; lars_kaestner@me.com" class="auth_mail" title="E-mail the corresponding author ; Peter Lippa ; peter.lipp@uks.eu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Endothelin-1 ; Phenylephrine ; Gq-coupled receptors ; Chronic stimulation ; Ca2+ sparks ; Ca2+ signalling ; Real time quantitative PCR ; Protein kinase C
- 刊名：Cell Calcium
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：59
- 期：1
- 页码：41-53
- 全文大小：2254 K
文摘
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Chronic (>1 week) Gq stimulation can be mimicked in a single cell model of adult cardiomyocytes.
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Endothelin-1 and phenylephrine increase cell arrhythmogenicity through genomic regulation.
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Expression of cardiac PKCγ is regulated by endothelin-1 and phenylephrine stimulation.
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Chronic endothelin-1 stimulation leads to a desensitization of its inotropic response in vivo.