Diet-induced obesity resistance of adult female mice selectively bred for increased wheel-running behavior is reversed by single perinatal exposure to a high-energy diet

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• 作者：Stefano Guidotti^a ; ^b ; ^{st.guidotti@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Neele Meyer^a ; ^{neele.meyer1@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Ewa Przybyt^c ; ^{ewaprzybyt@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Anton J.W. Scheurink^a ; ^{a.j.w.scheurink@rug.nl" class="auth_mail" title="E-mail the corresponding author} ; Martin C. Harmsen^c ; ^{m.c.harmsen@umcg.nl" class="auth_mail" title="E-mail the corresponding author} ; Theodore Garland Jr.^d ; ^{theodore.garland@ucr.edu" class="auth_mail" title="E-mail the corresponding author} ; Gertjan van Dijk^a ; ^b ; ^{gertjan.van.dijk@rug.nl" class="auth_mail" title="E-mail the corresponding author}
• 关键词：CON ; not selected control line ; DIO ; diet induced obesity ; HE ; high energy ; LF ; low fat ; MEO ; milk energy output ; MR ; metabolic rate ; OGTT ; oral glucose tolerance test ; PA ; physical activity ; RMR ; resting metabolic rate ; RQ ; respiratory quotient ; S ; mice selectively bred for increased voluntary wheel-running behavior
• 刊名：Physiology & Behavior
• 出版年：2016
• 出版时间：1 April 2016
• 年：2016
• 卷：157
• 期：Complete
• 页码：246-257
• 全文大小：1119 K

文摘

Female mice from independently bred lines previously selected over 50 generations for increased voluntary wheel-running behavior (S1, S2) resist high energy (HE) diet-induced obesity (DIO) at adulthood, even without actual access to running wheels, as opposed to randomly bred controls (CON). We investigated whether adult S mice without wheels remain DIO-resistant when exposed - via the mother - to the HE diet during their perinatal stage (from 2 weeks prior to conception until weaning on post-natal day 21). While S1 and S2 females subjected to HE diet either perinatally or from weaning onwards (post-weaning) resisted increased adiposity at adulthood (as opposed to CON females), they lost this resistance when challenged with HE diet during these periods combined over one single cycle of breeding. When allowed one-week access to wheels (at week 6–8 and at 10 months), however, tendency for increased wheel-running behavior of S mice was unaltered. Thus, the trait for increased wheel-running behavior remained intact following combined perinatal and post-weaning HE exposure, but apparently this did not block HE-induced weight gain. At weaning, perinatal HE diet increased adiposity in all lines, but this was only associated with hyperleptinemia in S lines irrespective of gender. Because leptin has multiple developmental effects at adolescence, we argue that a trait for increased physical activity may advance maturation in times of plenty. This would be adaptive in nature where episodes of increased nutrient availability should be exploited maximally. Associated disturbances in glucose homeostasis and related co-morbidities at adulthood are probably pleiotropic side effects.