Serotonin-mediated central fatigue underlies increased endurance capacity in mice from lines selectively bred for high voluntary wheel running
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- 作者：Gerald C. Claghorna ; Ivana A.T. Fonsecaa ; b ; Zoe Thompsona ; Curtis Barbera ; Theodore Garland Jr.a ; tgarland@ucr.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Exercise ; Experimental evolution ; Fatigue ; Genotype-by-environment interaction ; Serotonin ; Wheel running
- 刊名：Physiology & Behavior
- 出版年：2016
- 出版时间：1 July 2016
- 年：2016
- 卷：161
- 期：Complete
- 页码：145-154
- 全文大小：739 K
文摘
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Male mice were tested for forced treadmill endurance and voluntary wheel running.
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A serotonin (5-HT1A) agonist or antagonist (varying doses) was administered.
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The effect of each drug on endurance depended on genetic background.
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Effects on wheel running differed from effects on treadmill endurance.
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Results point to genetically determined control of endurance and fatigue.