Circulating levels of endocannabinoids respond acutely to voluntary exercise, are altered in mice selectively bred for high voluntary wheel running, and differ between the sexes

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• 作者：Zoe Thompson^a ; Donovan Argueta^b ; Theodore Garland Jr.^c ; ^{tgarland@ucr.edu} ; Nicholas DiPatrizio^b
• 关键词：Artificial selection ; Locomotor activity ; Reward ; Sex differences ; Training effect ; Voluntary exercise
• 刊名：Physiology & Behavior
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：170
• 期：Complete
• 页码：141-150
• 全文大小：664 K
• 卷排序：170

文摘

The endocannabinoid system is involved in regulation of voluntary locomotion. We studied 4 replicate lines of high runner (HR) mice bred for wheel exercise. Blood was collected during peak running on night 6 of wheel access. 2-AG and/or AEA levels differed between the sexes and between HR and control lines. Levels were also affected by wheel access (training effect) and acutely by activity.