Transcriptional regulation of the human Liver X Receptor α gene by Hepatocyte Nuclear Factor 4α
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- 作者：Dimitris Theofilatosa ; Aristomenis Anestisa ; Koshi Hashimotob ; Dimitris Kardassisa ; kardasis@imbb.forth.gr" class="auth_mail" title="E-mail the corresponding author
- 关键词：LXR ; HNF-4α ; Gene regulation ; HDL ; Oxysterols
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：469
- 期：3
- 页码：573-579
- 全文大小：872 K
文摘
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The human LXRα promoter contains a HNF-4α specific binding motif in the proximal −50/−40 region.
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Mutations in this motif abolished HNF4α binding and transactivation of the hLXRα promoter.
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Silencing of HNF-4α was associated with reduced LXRα protein levels and promoter activity.
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The HNF-4α/LXRα axis may have a wide role in cell and plasma cholesterol homeostasis.