Analysis of the impact of lung cancer treatment on nontuberculous mycobacterial lung diseases

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• 作者：Taisuke Tsuji^a ; ^{tsujita@kch.hosp.go.jp} ; Kazunari Tsuyuguchi^b ; ^{tsuyuguchi@kch.hosp.go.jp} ; Kazunobu Tachibana^a ; ^{ktachiba@kch.hosp.go.jp} ; Yohei Kimura^a ; ^{youhei-kimuta@hosp.go.jp} ; Takehiko Kobayashi^a ; ^{t-kobayashi@kch.hosp.go.jp} ; Shojiro Minomo^a ; ^{s-minomo@kch.hosp.go.jp} ; Shinji Atagi^b ; ^{s-atagi@kch.hosp.go.jp} ; Akihide Matsumura^c ; ^{a-matsumura@kch.hosp.go.jp} ; Seiji Hayashi^a ; ^{shayashi@kch.hosp.go.jp} ; Katsuhiro Suzuki ; M.D. ; Ph.D.^a ; ^{ksuzuki@kch.hosp.go.jp}
• 关键词：Nontuberculous mycobacteria ; Cytotoxic chemotherapy ; Lung cancer
• 刊名：Respiratory Investigation
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：55
• 期：1
• 页码：45-50
• 全文大小：346 K
• 卷排序：55

文摘

Although nontuberculous mycobacteria (NTM) lung diseases can occur in association with lung cancer, no study has evaluated the effect of lung cancer treatment on NTM lung diseases. Therefore, the present study aimed to retrospectively examine the effect of lung cancer treatment on NTM lung diseases.MethodsPatients diagnosed with NTM lung diseases in combination with cytologically or histologically proven lung cancer between January 1, 2010 and October 31, 2014 were enroled. The clinical history of eligible patients was retrospectively reviewed.ResultsSeven hundred twenty-eight patients were diagnosed with NTM lung diseases. Among these patients, 29 (3.9%) also had lung cancer. Of the 29 patients with NTM and lung cancer, 62% had Mycobacterium avium complex as the pathogenic organism. The most common lung cancer histology was adenocarcinoma (62.1%). Anti-cancer cytotoxic chemotherapy was administered to seven patients, and the two patients who did not receive NTM treatment showed worsening of their NTM lung disease.ConclusionWhether NTM lung disease should be treated during anti-cancer chemotherapy has not been not clarified by this study. Induction of anti-NTM therapy should be made after careful consideration, because the duration of anti-NTM treatment is long and anti-mycobacterial drugs have extensive effects on anti-cancer drugs. However, we think that anti-NTM therapy should be introduced after consideration of the worsening of symptoms and radiological findings associated with NTM lung disease.