Sustained remission including marked regression of a paravertebral plasmacytoma in a patient with heavily pretreated, relapsed multiple myeloma after treatment with bortezomib

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• 作者：Maria-Theresa Krauth ; Alexander Bankier ; Peter Valent ; Peter Kalhs and Johannes Drach
• 关键词：Multiple myeloma ; Bortezomib ; Proteasome-inhibitor ; Extramedullary manifestation
• 刊名：Leukemia Research
• 出版年：2005
• 出版时间：2005
• 年：2005
• 卷：29
• 期：12
• 页码：1473-1477
• 全文大小：211 K

文摘

Despite advances in systemic and supportive therapies, multiple myeloma (MM) has remained an incurable disease, which underlines the need for novel approaches to therapy. Recent data indicate that the proteasome-inhibitor bortezomib has marked activity with manageable toxicity in relapsed and refractory MM. We here report on a patient suffering from heavily pretreated and refractory MM with a paravertebral tumor manifestation. After three cycles of bortezomib, the patient achieved near-complete remission, as well as a nearly complete regression of the paravertebral tumor. This case further documents that bortezomib is an effective novel therapy for MM.