Neuropathological alterations in alcoholic brains. Studies arising from the New South Wales Tissue Resource Centre

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• 作者：Harper ; Clive ; Dixon ; Gavin ; Sheedy ; Donna ; Garrick ; Therese
• 关键词：Alcohol ; Brain bank ; Brain damage ; Donor program ; Neuropathology ; Pathology ; Quantitative ; DIBS ; diagnostic instrument for brain studies ; DIP ; diagnostic instrument for psychosis ; GABA ; gamma aminobutyric acid ; MRI ; magnetic resonance imaging ; NART ; Natio
• 刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry
• 出版年：2003
• 出版时间：September, 2003
• 年：2003
• 卷：27
• 期：6
• 页码：951-961
• 全文大小：280 K

文摘

Alcohol dependence and abuse are among the most costly health problems in the world from both social and economic points of view. Patterns of drinking appear to be changing throughout the world with more women and young people drinking heavily. Excessive drinking can lead to impairment of cognitive function and structural brain changes—some permanent, some reversible. Patterns of damage appear to relate to lifetime alcohol consumption but, more importantly, to associated medical complications. The most significant of these is the alcohol-related vitamin deficient state, the Wernicke–Korsakoff syndrome (WKS), which is caused by thiamin deficiency but is seen most commonly in alcoholics.