New insights into side effect of solvents on the aggregation of human islet amyloid polypeptide 11-20
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- 作者：Yexuan Maoa ; Lanlan Yua ; yulanlan@zzu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Ran Yanga ; Chuanguo Mac ; Ling-bo Qua ; b ; Peter de B. Harringtond
- 关键词：Microscale thermophoresis ; Molecular interaction ; Amyloid formation ; Islet amyloid polypeptide ; Solvent effect
- 刊名：Talanta
- 出版年：2016
- 出版时间：1 February 2016
- 年：2016
- 卷：148
- 期：Complete
- 页码：380-386
- 全文大小：1488 K
文摘
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A novel method microscale thermophoresis is used in studying aggregation behaviors.
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hIAPP11–20 displayed different aggregation behaviors in various buffers.
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Buffers exert significant effect on the aggregation of hIAPP11–20.
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hIAPP11–20 not only self-aggregates but also binds to solvent components.