In vitro CsG, CsA and FK506 hepatotoxicity study as a function of cytochrome P-450 3A induction

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• 作者：Ellouk-Achard ; Sophie ; Martin ; Chantal ; Chuong ; Pham-Huy ; Huynh ; Thien Duc ; Thevenin ; Marc ; et. al.
• 关键词：cyclosporin G ; cyclosporin A ; FK506 ; hepatotoxicity ; cytochrome P-450 3A ; in vitro
• 刊名：Toxicology Letters
• 出版年：1996
• 出版时间：October, 1996
• 年：1996
• 卷：88
• 期：Complete
• 页码：38
• 全文大小：132 K

文摘

FK506, cyclosporin A (CsA), and cyclosporin G (CsG), a structural analog, are immunosuppressant drugs mainly metabolized by hepatic cytochrome P-450 3A (CYP 3A) oxygenase. FK506 metabolites are more potent hepatotoxins than the parent drug, while CsA metabolites are far less toxic than CsA itself. The aim of our study was to compare the hepatotoxicity of CsG to that of CsA and FK506 as a function of CYP 3A induction.