New 6-amino-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines and [1,2,4]triazolo[3,4-b] [1,3,4]thiadiazin-6-ones: Synthesis, characterization and antibacterial activity evaluation

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• 作者：Gabriela Laura Almajan ; Stefania-Felicia Barbuceanu ; Ioana Saramet ; Constantin Draghici
• 关键词：Amino-triazolothiadiazines ; Triazolothiadiazinones ; Cyclodehydration ; Antibacterial activity
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2010
• 出版时间：July 2010
• 年：2010
• 卷：45
• 期：7
• 页码：3191-3195
• 全文大小：185 K

文摘

(4-X-Phenylsulfonyl)phenyl] containing 6-amino-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines and [1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-ones were synthesized by intermolecular condensation of 2-chloro-N-phenylacetamide, 2-chloroacetic acid, oxalylchloride and bromo-diethylmalonate with 4-amino-5-[4-(4-X-phenylsulfonyl)phenyl]-4H-1,2,4-triazole-3-thiols (X = H, Cl, Br). The structures of newly synthesized compounds were confirmed by elemental analysis and IR, NMR spectral data. All the compounds were screened for their antibacterial activities. Some of them exhibited good activities against Staphylococcus epidermidis ATCC 14990, Pseudomonas aeruginosa ATCC 9027, Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922.