Mechanisms and pharmacogenetic signals underlying thiazide diuretics blood pressure response
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- 作者：Mohamed H Shahin ; Julie A Johnson johnson@cop.ufl.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Current Opinion in Pharmacology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：27
- 期：Complete
- 页码：31-37
- 全文大小：471 K
文摘
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Thiazide's blood pressure mechanism is not only attributed to their diuretic effect.
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Thiazides act via multiple complex and interacting mechanisms.
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Thiazide's antihypertensive long term mechanism is mediated via direct vasodilation.
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Pharmacogenomic signals provide insight into thiazides’ antihypertensive mechanism.
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Pharmacogenomics may identify new targets for antihypertensive drug development.