Diuretics in primary hypertension - Reloaded

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• 作者：Sundeep Mishra ^{drsundeepmishra@hotmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Diuretics ; Hydrochlorothiazide ; Chlorthalidone ; Indapamide ; Mortality ; Cardiovascular outcome
• 刊名：Indian Heart Journal
• 出版年：2016
• 出版时间：September-October 2016
• 年：2016
• 卷：68
• 期：5
• 页码：720-723
• 全文大小：320 K

文摘

Diuretics have long been cherished as drugs of choice for uncomplicated primary hypertension. Robust mortality and morbidity data is available for diuretics to back this strategy. Off-late the interest for diuretics has waned off perhaps due to availability of more effective drugs but more likely due to perceived lack of tolerance and side-effect profile of high-dose of diuretics required for mortality benefit. Low-dose diuretics particularly thiazide diuretics are safer but lack the mortality benefit shown by high-dose. However, indapamide and low dose chlorthalidone have fewer side-effects but continue to provide mortality benefit.