Inhibition of dengue virus production and cytokine/chemokine expression by ribavirin and compound A
详细信息 查看全文
- 作者：Thidarath Rattanabureea ; b ; Mutita Junkinga ; Aussara Panyaa ; c ; Nunghathai Sawasdeea ; Pucharee Songprakhona ; Aroonroong Suttitheptumronga ; Thawornchai Limjindapornd ; Guy Haegemana ; Pa-thai Yenchitsomanusa ; pathai.yen@mahidol.ac.th" class="auth_mail" title="E-mail the corresponding author ; ptyench@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Dengue virus ; Compound A ; Ribavirin ; Cytokine ; Chemokine
- 刊名：Antiviral Research
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：124
- 期：Complete
- 页码：83-92
- 全文大小：2809 K
文摘
- •
Severity of dengue virus (DENV) infection correlates with high viral load and massive cytokine production.
- •
Ribavirin (RV) and compound A (CpdA) were tested in DENV-infected A549 cells.
- •
RV significantly reduced DENV production, cytokine (IL-6 and TNF-alpha) and chemokine (IP-10, and RANTES) transcription.
- •
CpdA significantly reduced cytokine/chemokine (IL-6, TNF-alpha, and RANTES) transcription.
- •
Combined RV and CpdA treatment resulted in greater reduction of DENV production and cytokine/chemokine transcription.