MarginProbe^庐 - Final results of the German post-market study in breast conserving surgery of ductal carcinoma in situ

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• 作者：Marc Thill ; Christine Dittmer ; Kristin Baumann ; Kay Friedrichs ; Jens-Uwe Blohmer
• 关键词：Ductal carcinoma in situ ; Breast conservation surgery ; Intraoperative margin assessment ; Surgical margins ; Radiofrequency spectroscopy
• 刊名：The Breast
• 出版年：February, 2014
• 年：2014
• 卷：23
• 期：1
• 页码：94-96
• 全文大小：178 K

文摘

The goal in breast conserving surgery (BCS) of ductal carcinoma in situ (DCIS) is removal of the tumor with a clear surgical margin. However, re-excision rates are regrettably high. To date, there are no adequate procedures for intraoperative margin assessment of DCIS. A multicenter, single arm study was conducted to evaluate the benefit of a novel device (MarginProbe^庐) in intraoperative margin assessment during BCS of DCIS, the associated reduction of re-excisions and the cosmetic outcome of the treated patients. We present results of 42 patients enrolled in 3 German institutions. The device was used as an adjunctive tool to standard of care. The device use was associated with a reduction in re-excision rates by 56%, from 39% to 17% (p聽=聽0.018).