The Central-European SentiMag study: Sentinel lymph node biopsy with superparamagnetic iron oxide (SPIO) vs. radioisotope

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• 作者：Marc Thill^a ; ^{marc.thill@fdk.info" class="auth_mail} ; Andrzej Kurylcio^b ; Rebekka Welter^c ; Viviana van Haasteren^a ; Britta Grosse^a ; Gilles Berclaz^d ; Wojciech Polkowski^b ; Nik Hauser^c
• 关键词：Invasive breast cancer ; Sentinel lymph node biopsy ; Superparamagnetic iron oxide (SPIO) ; SentiMag® ; Sienna+®
• 刊名：The Breast
• 出版年：April, 2014
• 年：2014
• 卷：23
• 期：2
• 页码：175-179
• 全文大小：737 K

文摘

Sentinel lymph node biopsy (SLNB) is the standard surgical procedure for the axilla in early node-negative breast cancer. To date, the 鈥済old standard鈥?to localize the sentinel lymph node (SLN) is the radiotracer ^99mTc with or without blue dye. The aim of this study was to evaluate potential equivalency of the new SentiMag^庐 technique in comparison to the 鈥済old standard鈥? Within this prospective, multicentric and multinational non-inferiority study including 150 patients ^99mTc was compared with the magnetic technique, using superparamagnetic iron oxide particles (SPIOs, Sienna+^庐) for localization of SLNs. The results showed a detection rate per patient of 97.3% (146/150) for ^99mTc vs. 98.0% (147/150) for Sienna+^庐 with a similar average number of removed SLNs per patient and a higher per patient malignancy detection rate for the SPIO tracer. We obtained convincing results that magnetic SLNB can be performed easily, safely and equivalently well in comparison to the radiotracer method.