Increased striatal VMAT2 binding in mice after chronic administration of methcathinone and manganese
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- 作者：Andres Assera ; Sulev Kõ ; ksb ; Anniina Snellmanc ; Merja Haaparanta-Solinc ; Eveliina Arponenc ; Tove Grö ; nroosc ; Jaak Nairismä ; gid ; Jonas Bergquiste ; Ursel Soometsf ; Piret Piipa ; Mall Eltermaaa ; Martin Sauka ; Hanna Lindmä ; ea ; Juha O. Rinnec ; g ; Pille Tabaa ; pille.taba@kliinikum.ee" class="auth_mail" title="E-mail the corresponding author
- 关键词：Manganism ; Ephedrone ; Methcathinone ; VMAT2 ; PET
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 December 2016
- 年：2016
- 卷：1652
- 期：Complete
- 页码：97-102
- 全文大小：617 K
文摘
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Methcathinone and manganese containing neurotoxic mixture is injected by drug abusers.
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Drug mixture use leads to a non-treatable parkinsonian syndrome in humans.
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Chronic administration of the compounds leads to an extrapyramidal syndrome in mice.
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PET imaging shows altered VMAT2 function after chronic use of the mixture.