Sensitization to the locomotor stimulant effects of “bath salt” constituents, 4‐methylmethcathinone (4-MMC) and 3,4-methylenedioxypyrovalerone (MDPV), in male Sprague-Dawley rats
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Locomotor activity sensitized to MDPV and to low dose mixtures of 4-MMC and MDPV.

Cross‐sensitization to cocaine was evident following exposure to MDPV and 4-MMC.

Studies on the abuse liability of synthetic cathinone mixtures may be warranted.

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