Synthesis and antibacterial activity of substituted flavones, 4-thioflavones and 4-iminoflavones

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• 作者：Ehsan Ullah Mughal ; Muhammad Ayaz ; Zakir Hussain ; Aurangzeb Hasan ; Amina Sadiq ; Muhammad Riaz ; Abdul Malik ; Samreen Hussain and M. Iqbal Choudhary
• 关键词：Synthesis ; Flavones ; 4-Thioflavones ; 4-Iminoflavones ; Antibacterial
• 刊名：Bioorganic and Medicinal Chemistry
• 出版年：2006
• 出版时间：15 July 2006
• 年：2006
• 卷：14
• 期：14
• 页码：4704-4711
• 全文大小：165 K

文摘

Synthesis of flavones, 4-thioflavones and 4-iminoflavones was carried out with the substitution of variable halogens, methyl, methoxy and nitro groups in the A, B and AB rings of the respective compounds and we also report here their antibacterial activity. Most of the synthesized compounds were found to be active against Escherichia coli, Bacillus subtilis, Shigella flexnari, Salmonella aureus, Salmonella typhi and Pseudomonas aeruginosa. Activity of 4-thioflavones and 4-iminoflavones was found to be higher than that of their corresponding flavone analogues. Investigated compounds having substituents like F, OMe and NO₂ at 4′-position in ring-B exhibited enhanced activity and the presence of electronegative groups in the studied compounds showed a direct relationship to the antibacterial activity.