Palladium mediated stereospecific synthesis of 3-enynyl substituted thioflavones/flavones
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- 作者：Pal ; Manojit ; Parasuraman ; Karuppasamy ; Subramanian ; Venkataraman ; Dakarapu ; Rambabu ; Yeleswarapu ; Koteswar Rao
- 关键词：3-Enynyl/alkynyl thioflavones ; Stereocontrolled synthesis ; Palladium catalyst ; 3-Iodo(thio)flavone
- 刊名：Tetrahedron Letters
- 出版年：2004
- 出版时间：March 8, 2004
- 年：2004
- 卷：45
- 期：11
- 页码：2305-2309
- 全文大小：288 K
文摘
The stereocontrolled synthesis of enynes has been accomplished via a sequential Heck–Sonogashira reaction in a simple synthetic operation. A variety of terminal alkynes were reacted with 3-iodo(thio)flavone in the presence of a palladium catalyst and a copper salt affording a mild and one-pot method for the first synthesis of the corresponding 3-enynyl and/or alkynyl derivatives. The mechanism and scope of the reaction are discussed.