Finding of thiosulfate pathway for synthesis of organic sulfur compounds in Saccharomyces cerevisiae and improvement of ethanol production

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• 作者：Eri Funahashi¹ ; ^&Dagger ; ; Kyohei Saiki¹ ; ^&Dagger ; ; Kurara Honda⁴ ; Yuki Sugiura⁴ ; Yusuke Kawano¹ ; Iwao Ohtsu¹ ; ^{iohtsu@bs.naist.jp" class="auth_mail" title="E-mail the corresponding author} ; Daisuke Watanabe¹ ; Yukari Wakabayashi² ; Tetsuya Abe² ; Tsuyoshi Nakanishi³ ; Makoto Suematsu⁴ ; Hiroshi Takagi¹
• 关键词：Saccharomyces cerevisiae ; Thiosulfate assimilation ; Ethanol production ; Pentose phoshate pathway ; Sulfur metabolism ; Sulfur metabolome
• 刊名：Journal of Bioscience and Bioengineering
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：120
• 期：6
• 页码：666-669
• 全文大小：729 K

文摘

We found that Saccharomyces cerevisiae utilizes thiosulfate as a sole sulfur source. The energetically-favored thiosulfate rather than sulfate as sulfur sources is also more effective for improving growth and ethanol-production rate in S. cerevisiae due to high levels of intracellular NADPH during thiosulfate utilization.