Synthesis, antimicrobial and antioxidant activities of substituted pyrazoles, isoxazoles, pyrimidine and thioxopyrimidine derivatives
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- 作者：A. Padmaja ; T. Payani ; G. Dinneswara Reddy ; V. Padmavathi
- 关键词：Malononitrile ; Diaminopyrazoles ; Aminoiminoisoxazoles ; Diaminopyrimidines ; Diaminothioxopyrimidines ; N ; N′ ; -Dimethyldiiminopyrimidines ; Michael addition ; Antimicrobial activity ; Antioxidant activity
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2009
- 出版时间：November 2009
- 年：2009
- 卷：44
- 期：11
- 页码：4557-4566
- 全文大小：289 K
文摘
A new class of heterocycles, substituted pyrazoles, isoxazoles, pyrimidines, thioxopyrimidines were prepared from Michael adducts, 2-(1,2-diaroylethyl)malononitrile and 2-(1,2-diarylsulfonylethyl)malononitrile by cyclocondensation with appropriate nucleophiles. The lead compounds were screened for the antimicrobial and antioxidant activities.