An endophytic fungus from surface-sterilized leaves of Silybum marianum (milk thistle) was investigated.
A total of five compounds was isolated from the fungal endophyte, Talaromyces minioluteus.
Among them, four were identified as meroterpenoids (named talarolutins A–D).
These meroterpenoids are of mixed biosynthetic origin, likely derived from terpene and polyketide subunits.
X-ray crystallography, NMR, and MS techniques were utilized for determining the structures of the compounds.