Identification of intracellular proteins and signaling pathways in human endothelial cells regulated by angiotensin-(1-7)
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- 作者：Christian Meinerta ; b ; Florian Gembardtc ; Ilka Bö ; hmed ; Anja Tetznerb ; d ; Thomas Wielanda ; Barry Greenberge ; Thomas Walthera ; b ; d ; thomas.walther2011@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Angiotensin-(1-7) ; Antibody microarray ; Cell signaling ; Endothelium ; Renin-angiotensin system
- 刊名：Journal of Proteomics
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：130
- 期：Complete
- 页码：129-139
- 全文大小：1950 K
文摘
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Ang-(1–7) regulates proteins in a time-dependent manner in endothelial cells.
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Such proteins associate to metabolic pathways related to cell death and cell survival.
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Microarrays and Western blots identified downregulation of PIAS2 FBI-1/Pokemon.
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Changes in both proteins but not their RNA implicate posttranscriptional regulation.
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Regulation pattern of both proteins was similar in different endothelial cell types.