Reduced Cognition in Syngap1 Mutants Is Caused by Isolated Damage within Developing Forebrain Excitatory Neurons
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- 作者：Emin D. Ozkan1 ; 5 ; Thomas K. Creson1 ; 5 ; Enikö ; A. Kramá ; r2 ; Camilo Rojas1 ; Ron R. Seese2 ; Alex H. Babyan2 ; Yulin Shi2 ; Rocco Lucero3 ; Xiangmin Xu2 ; Jeffrey L. Noebels3 ; Courtney A. Miller1 ; 4 ; Gary Lynch2 ; Gavin Rumbaugh1 ; grumbaug@scripps.edu" class="auth_mail
- 刊名：Neuron
- 出版年：18 June 2014
- 年：2014
- 卷：82
- 期：6
- 页码：1317-1333
- 全文大小：8319 K
文摘
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Adult Syngap1 mutants have altered cortical rhythms and network hyperexcitability
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Early glutamatergic neuron dysfunction is necessary and sufficient to cause phenotype
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Early glutamatergic neuron dysfunction causes synaptic dyshomeostasis in adulthood
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Excitatory synaptic dyshomeostasis predicts cognitive dysfunction