Two competing reactions of tetrabutylammonium alginate in organic solvents: Amidation versus γ-lactone synthesis
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- 作者：Thomas Schleeha ; thomas.schleeh@list.lu" class="auth_mail" title="E-mail the corresponding author ; Mathieu Madaua ; Dierk Roessnerb
- 关键词：Mannuronic acid γ-lactone ; Conformation change ; 2-Chloro-1-methylpyridinium iodide ; Propylphosphonic anhydride ; Alginic acid alkyl amide
- 刊名：Carbohydrate Polymers
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：138
- 期：Complete
- 页码：244-251
- 全文大小：875 K
文摘
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Mannuronic acid γ-lactone synthesis from TBA alginate with T3P and CMPI.
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Mannuronic acid γ-lactone formation required a conformation change from 1C4 to 4C1.
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Opening of the mannuronic acid γ-lactone required a high excess of butylamine.
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Alginic acid butyl amide synthesis with T3P resulted in a DSamide ∼ 1.