Programmed Ribosomal Frameshifting Generates a Copper Transporter and a Copper Chaperone from the Same Gene

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• 作者：Sezen Meydan¹ ; Dorota Klepacki¹ ; Subbulakshmi Karthikeyan¹ ; Tõ ; nu Margus¹ ; Paul Thomas² ; John E. Jones³ ; Yousuf Khan³ ; Joseph Briggs³ ; Jonathan D. Dinman³ ; Nora Vá ; zquez-Laslop¹ ; ^{nvazquez@uic.edu} ; Alexander S. Mankin¹ ; ⁴ ; ^{shura@uic.edu}
• 关键词：translation regulation ; ribosome profiling ; nascent peptide ; slippery sequence ; pseudoknot ; copA ; recoding
• 刊名：Molecular Cell
• 出版年：2017
• 出版时间：19 January 2017
• 年：2017
• 卷：65
• 期：2
• 页码：207-219
• 全文大小：1876 K
• 卷排序：65

文摘

Programmed ribosomal frameshifting occurs in the E. coli copper transporter gene copA The copper chaperone resulting from the frameshift contributes to copper tolerance A slippery sequence, an mRNA structure, and the CopA nascent chain stimulate the event copA frameshifting elements are found in several bacteria and the human ATP7B gene