Hepatocyte-specific Keap1 deletion reduces liver steatosis but not inflammation during non-alcoholic steatohepatitis development
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- 作者：Pierluigi Ramadoria ; pramadori@ukaachen.de" class="auth_mail" title="E-mail the corresponding author ; Hannah Dreschera ; Stephanie Erschfelda ; Fabienne Schumachera ; Cordula Bergera ; Athanassios Fragoulisb ; Julia Schenkelb ; Thomas W. Kenslerc ; Christoph J. Wruckb ; Christian Trautweina ; Daniela C. Kroya ; 1 ; Konrad L. Streetza ; 1 ; kstreetz@ukaachen.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Nrf2 ; LXRα/β ; Lipid metabolism ; Oxidative stress ; Bcl-2
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：91
- 期：Complete
- 页码：114-126
- 全文大小：5014 K
文摘
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We challenged hepatocyte-specific Keap1 knockout mice with two different models of non-alcoholic steatohepatitis.
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Lack of Keap1 resulted in reduced liver steatosis via inhibition of lipogenesis and enhanced mitochondrial functionality.
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Hepatocyte-specific Keap1 deletion significantly decreased apoptotic cell death.
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Hepatocyte-specific Keap1 deletion did not attenuate hepatic inflammation and fibrosis.