Type 2 Interleukin-4 Receptor Signaling in Neutrophils Antagonizes Their Expansion and Migration during Infection and Inflammation
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- 作者：Janine Woytschak1 ; Nadia Keller2 ; Carsten Krieg3 ; Daniela Impellizzieri1 ; Robert W. Thompson4 ; Thomas A. Wynn4 ; Annelies S. Zinkernagel2 ; Onur Boyman1 ; onur.boyman@uzh.ch" class="auth_mail" title="E-mail the corresponding author
- 刊名：Immunity
- 出版年：2016
- 出版时间：19 July 2016
- 年：2016
- 卷：45
- 期：1
- 页码：172-184
- 全文大小：3632 K
文摘
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Cutaneous and systemic bacterial infections are exacerbated by IL-4 signaling
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IL-4 restricts neutrophil expansion in and migration from bone marrow to tissues
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IL-4 opposes G-CSF effects by direct action on neutrophils via type 2 IL-4Rs
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IL-4 interferes with CXCR2-CXCR4 and p38 MAPK-PI3K regulation in neutrophils