Esophageal Diameter Is Decreased in Some Patients With Eosinophilic Esophagitis and Might Increase With Topical Corticosteroid Therapy

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• 作者：Joohee Lee^?/sup> ; James Huprich^&Dagger ; ; Christine Kujath^&sect ; ; Karthik Ravi^&sect ; ; Felicity Enders^?/sup> ; Thomas C. Smyrk^¶ ; ; David A. Katzka^&sect ; ; Nicholas J. Talley^# ; Jeffrey A. Alexander^&sect ; ; ^{alexander.jeffrey14@mayo.edu}
• 关键词：Eosinophilic Esophagitis ; Dysphagia ; Esophageal Distensibility
• 刊名：Clinical Gastroenterology and Hepatology
• 出版年：2012
• 出版时间：May, 2012
• 年：2012
• 卷：10
• 期：5
• 页码：481-486
• 全文大小：824 K

文摘

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Background & Aims

The rapid response to topical corticosteroids makes it hard to implicate fibrosis as the cause of dysphagia in patients with eosinophilic esophagitis (EoE). We examined surrogates of esophageal expansion using minimal and maximal esophageal diameter (EDmin and EDmax) in barium swallow examinations.

Methods

Eleven patients evaluated at Mayo Clinic, Rochester (8 female, median age 40, median diagnosis 36 months, median symptom duration 132 months) underwent barium esophagrams to determine EDmin and EDmax before and after 6 weeks of topical corticosteroid therapy. We assessed parameter reproducibility (in healthy volunteers), baseline EDmin and EDmax, postcorticosteroid changes in EoE patients, and correlation with clinical response.

Results

EDmin and EDmax were reproducible, with nonsignificant variance in the 2 esophagrams in control subjects (P = .44 and P = .66, respectively). Baseline EDmax was reduced in EoE at 19 mm (range, 13-26 mm) vs 24 mm (range, 19-29 mm) in controls (P = .004). About 50 % of the EoE patients had EDmax and min values within the 10th to 90th percentile of controls (45 % and 55 % , respectively). Clinical improvement by Mayo Dsyphagia Questionnaire did not correlate with postcorticosteroid luminal change (P = .19 for EDmax; P = .75 for EDmin). Median increases in postcorticosteroid EDmax and EDmin were not statistically significant (P = .15 and .1, respectively). However, they were significant in patients with abnormal baseline EDmax (n = 6; 2 mm; P = .01) and EDmin (n = 5; 3 mm; P = .02).

Conclusions

Esophageal diameter is a reproducible parameter that is frequently decreased in EoE, but normal in approximately 50 % of patients. Those with narrowing might respond to steroids, but it is unclear if narrowing causes dysphagia.