Synthesis and evaluation of C9 alkoxy analogues of (-)-stepholidine as dopamine receptor ligands

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• 作者：Sudharshan Madapa^a ; Satishkumar Gadhiya^a ; ^b ; Thomas Kurtzman^b ; ^c ; ^d ; Ian L. Alberts^e ; Steven Ramsey^c ; ^d ; Maarten Reith^f ; Wayne W. Harding^a ; ^b ; ^c ; ^{whardi@hunter.cuny.edu}
• 关键词：Dopamine ; D1 ; D3 ; Tetrahydroprotoberberine ; THPB ; Stepholidine
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：125
• 期：Complete
• 页码：255-268
• 全文大小：2000 K
• 卷排序：125

文摘

C9 alkoxy analogues were evaluated for affinity at D1, D2 and D3 receptors. The analogues retain selectivity for the D1 receptor. Docking studies revealed a number of key residues important for D3 affinity.