- 作者：Maike vom Hove ; Freerk Prenzel ; Holm H. Uhlig ; Eva Robel-Tillig
- 关键词：ATS ; American Thoracic Society ; BPD ; Bronchopulmonary dysplasia ; DLCO ; Transfer factor of carbon monoxide ; ERS ; European Respiratory Society ; FEF25/FEF50/FEF75 ; Forced expiratory flow rate at 25%/50%/75% of forced vital capacity ; FEF25-75 ; Forced expiratory flow rate between 25% and 75% of expired forced vital capacity ; FEV1 ; Forced expiratory volume in 1 second ; FVC ; Forced vital capacity ; PMA ; Postmenstrual age ; RAW ; Airway resistance ; RV ; Residual volume ; TLC ; Total lung capacity ; VLBW ; Very
- 刊名：The Journal of Pediatrics
- 出版年：January, 2014
- 年：2014
- 卷：164
- 期：1
- 页码：40-45.e4
- 全文大小：600 K
Objective
To assess and compare long-term pulmonary outcomes in former preterm-born, very low birth weight (VLBW) children with and without bronchopulmonary dysplasia (BPD) born in the surfactant era.Study design
Pulmonary function tests (ie, spirometry, body plethysmography, and gas transfer testing) were performed in children with a history of VLBW and BPD (n = 28) and compared with a matched preterm-born VLBW control group (n = 28). Medical history was evaluated by questionnaire.
Results
At time of follow-up (mean age, 9.5 years), respiratory symptoms (36% vs 8%) and receipt of asthma medication (21% vs 0%) were significantly more frequent in the preterm-born children with previous BPD than in those with no history of BPD. The children with a history of BPD had significantly lower values for forced expiratory volume in 1 second (z-score 鈭?.27 vs 鈭?.4; P = .008), forced vital capacity (z-score 鈭?.39 vs 鈭?.71 z-score; P聽=聽.022), and forced expiratory flow rate at 50% of forced vital capacity (z-score 鈭?.21 vs 鈭?.04; P = .048) compared with the preterm control group.
Conclusion
Preterm-born children with a history of BPD are significantly more likely to have lung function abnormalities, such as airway obstruction and respiratory symptoms, at school age compared with preterm-born children without BPD.