B-cell responses after intranasal vaccination with the novel attenuated Bordetella pertussis vaccine strain BPZE1 in a randomized phase I clinical trial
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- 作者：Maja Jahnmatza ; b ; maja.jahnmatz@folkhalsomyndigheten.se" class="auth_mail ; Sylvie Amub ; Margaretha Ljungmana ; Lena Wehlina ; Francesca Chiodib ; Nathalie Mielcarekc ; d ; e ; f ; Camille Lochtc ; d ; e ; f ; Rigmor Thorstenssona
- 关键词：ASC ; antibody secreting cells ; FHA ; filamentous hemagglutinin ; Pa ; acellular pertussis vaccine ; PRN ; pertactin ; PT ; pertussis toxin ; Pw ; whole cell pertussis vaccine ; TTd ; tetanus toxoid
- 刊名：Vaccine
- 出版年：5 June 2014
- 年：2014
- 卷：32
- 期：27
- 页码：3350-3356
- 全文大小：1548 K
文摘
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The immunogenicity of a novel live attenuated pertussis vaccine, BPZE1, was evaluated.
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After intranasal vaccination of BPZE1 B-cell responses were tested in a phase I clinical trial.
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Seven of 36 subjects were colonized and mounted strong B-cell responses.