Decreased OxLDL uptake and cholesterol efflux in THP1 cells elicited by cortisol and by cortisone through 11β-hydroxysteroid dehydrogenase type 1
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- 作者：Angelo Leddaa ; b ; Marina Gonzá ; lezc ; 1 ; José ; Gulfoa ; b ; Ivo Dí ; az Ludovicoc ; Nahuel Ramellac ; Juan Toledoc ; Horacio Gardac ; Mar Grasaa ; b ; 1 ; Montserrat Estevea ; b ; 1 ; mesteve@ub.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cortisol ; Cortisone ; 11β-hydroxysteroid dehydrogenase 1 ; 11β-hydroxysteroid dehydrogenase 2 ; THP1 macrophages ; Foam cells
- 刊名：Atherosclerosis
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：250
- 期：Complete
- 页码：84-94
- 全文大小：2490 K
文摘
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Research about the glucocorticoids role in foam cells formation from THP1 macrophages.
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Cortisol diminished the OxLDL uptake, cholesterol esterification and its efflux.
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The overall effect of cortisol was reduce lipid charge and formation of foam cells.
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Cortisone mimics the effects of cortisol through 11β-HSD1.