A meta-analysis of the effects of aging on motor cortex neurophysiology assessed by transcranial magnetic stimulation
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- 作者：Apoorva Bhandaria ; Natasha Radhua ; Faranak Farzana ; b ; c ; Benoit H. Mulsanta ; b ; c ; Tarek K. Rajjia ; b ; c ; Zafiris J. Daskalakisa ; b ; c ; Daniel M. Blumbergera ; b ; c ; daniel.blumberger@camh.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：TMS ; transcranial magnetic stimulation ; GABA ; gamma-aminobutyric acid ; RMT ; resting motor threshold ; SICI ; short-interval cortical inhibition ; SAI ; short-latency afferent inhibition ; CSP ; cortical silent period ; ICF ; intracortical facilitation ; PAS ; paired associative stimulation ; LTP ; long-term potentiation ; LTD ; long-term depression ; NMDA ; N-methyl-d-aspartate ; EMG ; electromyography ; ISI ; interstimulus interval ; CI ; confidence interval ; SD ; standard deviation ; CNS ; central nervous system ; PNS
- 刊名：Clinical Neurophysiology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：127
- 期：8
- 页码：2834-2845
- 全文大小：760 K
文摘
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TMS measures of motor cortical excitation, inhibition and plasticity were assessed in young vs older adults.
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Age-related motor cortical hypo-excitability and a trending decrease in LTP-like plasticity observed.
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Older adults showed deficits in sensorimotor integration in comparison to young adults.